6Q92

Crystal structure of human Arginase-1 at pH 7.0 in complex with ABH

Summary for 6Q92

• Entry DOI: 10.2210/pdb6q92/pdb
• Descriptor: Arginase-1, MANGANESE (II) ION, 2(S)-AMINO-6-BORONOHEXANOIC ACID, ... (5 entities in total)
• Functional Keywords: hydrolase inhibitor, borate, manganese cluster, ph-dependent, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 74552.18

Authors

Grobben, Y.,Uitdehaag, J.C.M.,Zaman, G.J.R. (deposition date: 2018-12-17, release date: 2019-12-11, Last modification date: 2024-01-24)

• Primary citation: Grobben, Y.,Uitdehaag, J.C.M.,Willemsen-Seegers, N.,Tabak, W.W.A.,de Man, J.,Buijsman, R.C.,Zaman, G.J.R.; Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.; J Struct Biol X, 4:100014-100014, 2020; PubMed: 32647818; DOI: 10.1016/j.yjsbx.2019.100014

Experimental method

X-RAY DIFFRACTION (1.5 Å)