6QAF
Crystal structure of human Arginase-1 at pH 9.0 in complex with CB-1158/INCB001158
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Arginase-1 | polymer | 342 | 36951.2 | 2 | UniProt (P05089) Pfam (PF00491) In PDB | Homo sapiens (Human) | Liver-type arginase,Type I arginase |
2 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
3 | A, B | [(~{E})-3-[(3~{S},4~{R})-4-azanyl-1-[(2~{S})-2-azanylpropanoyl]-4-carboxy-pyrrolidin-3-yl]prop-1-enyl]-tris(oxidanyl)boranium | non-polymer | 302.1 | 2 | Chemie (XC3) | |||
4 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | water | water | 18.0 | 376 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 322 (UniProt: P05089)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73902.5 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 870.0 | |
All* | Total formula weight | 74772.4 |