6Q9S

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 14 AT 2.4A: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Summary for 6Q9S

• Entry DOI: 10.2210/pdb6q9s/pdb
• Related: 6Q9Q
• Descriptor: Protein Mdm4, 3-[[6-chloranyl-3-[3-[(1~{S})-1-(2,4-dichlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]carbonylamino]-4-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]benzoic acid, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... (6 entities in total)
• Functional Keywords: hdmx, mdm4, apoptosis
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 39982.75

Authors

Kallen, J. (deposition date: 2018-12-18, release date: 2019-05-15, Last modification date: 2024-01-24)

• Primary citation: Kallen, J.,Izaac, A.,Chau, S.,Wirth, E.,Schoepfer, J.,Mah, R.,Schlapbach, A.,Stutz, S.,Vaupel, A.,Guagnano, V.,Masuya, K.,Stachyra, T.M.,Salem, B.,Chene, P.,Gessier, F.,Holzer, P.,Furet, P.; Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.; Chemmedchem, 14:1305-1314, 2019; PubMed: 31066983; DOI: 10.1002/cmdc.201900201

Experimental method

X-RAY DIFFRACTION (2.4 Å)