6Q94
Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-Man
Summary for 6Q94
Entry DOI | 10.2210/pdb6q94/pdb |
Descriptor | GDP-mannose 4,6 dehydratase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... (5 entities in total) |
Functional Keywords | gdp-mannose 4, 6 dehydratase, fucosylation, structural genomics, structural genomics consortium, sgc, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 331714.02 |
Authors | Pfeiffer, M.,Krojer, T.,Johansson, C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Nidetzky, B.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-17, release date: 2019-04-24, Last modification date: 2024-05-15) |
Primary citation | Pfeiffer, M.,Johansson, C.,Krojer, T.,Kavanagh, K.L.,Oppermann, U.,Nidetzky, B. A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. Acs Catalysis, 9:2962-2968, 2019 Cited by PubMed: 30984471DOI: 10.1021/acscatal.9b00064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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