6Q8K
CLK1 with bound pyridoquinazoline
Summary for 6Q8K
Entry DOI | 10.2210/pdb6q8k/pdb |
Descriptor | Dual specificity protein kinase CLK1, 1,2-ETHANEDIOL, ~{N}2-(3-morpholin-4-ylpropyl)pyrido[3,4-g]quinazoline-2,10-diamine, ... (4 entities in total) |
Functional Keywords | clk1, dual specifity protein kinase clk1, inhibitor, kinase, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39981.99 |
Authors | Schroeder, M.,Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.,Khiari, J.,Joesselin, B.,Bach, S.,Ruchaud, S.,Anizon, F.,Giraud, F.,Moreau, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-14, release date: 2019-02-20, Last modification date: 2024-05-15) |
Primary citation | Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.,Knapp, S.,Chatterjee, D.,Schroder, M.,Joerger, A.C.,Khiari, J.,Josselin, B.,Baratte, B.,Bach, S.,Ruchaud, S.,Anizon, F.,Giraud, F.,Moreau, P. New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem, 166:304-317, 2019 Cited by PubMed: 30731399DOI: 10.1016/j.ejmech.2019.01.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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