6Q8J

Nterminal domain of human SMU1 in complex with LSP641

Summary for 6Q8J

Related6Q8F 6Q8I
DescriptorWD40 repeat-containing protein SMU1, 1-~{tert}-butyl-3-[6-(3,5-dimethoxyphenyl)-2-[[1-[1-(phenylmethyl)piperidin-4-yl]-1,2,3-triazol-4-yl]methylamino]pyrido[2,3-d]pyrimidin-7-yl]urea (3 entities in total)
Functional Keywordssplicing factor, influenza virus, splicing
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight23416.98
Authors
Primary citation
Ashraf, U.,Tengo, L.,Le Corre, L.,Fournier, G.,Busca, P.,McCarthy, A.A.,Rameix-Welti, M.A.,Gravier-Pelletier, C.,Ruigrok, R.W.H.,Jacob, Y.,Vidalain, P.O.,Pietrancosta, N.,Crepin, T.,Naffakh, N.
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116:10968-10977, 2019
PubMed: 31076555 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1901214116
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23240 1.2% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution