6Q8J

Nterminal domain of human SMU1 in complex with LSP641

6Q8J の概要

関連するPDBエントリー6Q8F 6Q8I
分子名称WD40 repeat-containing protein SMU1, 1-~{tert}-butyl-3-[6-(3,5-dimethoxyphenyl)-2-[[1-[1-(phenylmethyl)piperidin-4-yl]-1,2,3-triazol-4-yl]methylamino]pyrido[2,3-d]pyrimidin-7-yl]urea (3 entities in total)
機能のキーワードsplicing factor, influenza virus, splicing
由来する生物種Homo sapiens (Human)
ポリマー鎖数1
分子量合計23416.98
構造登録者
主引用文献
Ashraf, U.,Tengo, L.,Le Corre, L.,Fournier, G.,Busca, P.,McCarthy, A.A.,Rameix-Welti, M.A.,Gravier-Pelletier, C.,Ruigrok, R.W.H.,Jacob, Y.,Vidalain, P.O.,Pietrancosta, N.,Crepin, T.,Naffakh, N.
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116:10968-10977, 2019
PubMed: 31076555 (主引用文献が同じPDBエントリー)
DOI: 10.1073/pnas.1901214116
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.8 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23240 1.2% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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