6Q7V

Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 11

6Q7V の概要

• エントリーDOI: 10.2210/pdb6q7v/pdb
• 分子名称: Transcriptional regulator MvfR, ~{N}4-[(4-fluorophenyl)methyl]-6-(trifluoromethyl)pyridine-2,4-diamine (3 entities in total)
• 機能のキーワード: quorum sensing, lysr-type transcriptional regulator, pseudomonas quinolone signaling system, lttr, dna binding protein
• 由来する生物種: Pseudomonas aeruginosa PAO1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51970.62

構造登録者

Witzgall, F.,Blankenfeldt, W. (登録日: 2018-12-13, 公開日: 2019-11-20, 最終更新日: 2024-01-24)

• 主引用文献: Zender, M.,Witzgall, F.,Kiefer, A.,Kirsch, B.,Maurer, C.K.,Kany, A.M.,Xu, N.,Schmelz, S.,Borger, C.,Blankenfeldt, W.,Empting, M.; Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.; Chemmedchem, 15:188-194, 2020; PubMed: 31709767; DOI: 10.1002/cmdc.201900621

実験手法

X-RAY DIFFRACTION (2.56 Å)