6Q54
Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution
Summary for 6Q54
Entry DOI | 10.2210/pdb6q54/pdb |
Descriptor | Glutamate receptor 2, SULFATE ION, (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, ... (10 entities in total) |
Functional Keywords | ionotropic glutamate receptor, ampa receptor, ligand-binding domain, glua2-s1s2, glua2, glur2, agonist, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 61012.63 |
Authors | Moellerud, S.,Temperini, P.,Kastrup, J.S. (deposition date: 2018-12-07, release date: 2019-04-17, Last modification date: 2024-01-24) |
Primary citation | Sainas, S.,Temperini, P.,Farnsworth, J.C.,Yi, F.,Mollerud, S.,Jensen, A.A.,Nielsen, B.,Passoni, A.,Kastrup, J.S.,Hansen, K.B.,Boschi, D.,Pickering, D.S.,Clausen, R.P.,Lolli, M.L. Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J.Med.Chem., 62:4467-4482, 2019 Cited by PubMed: 30943028DOI: 10.1021/acs.jmedchem.8b01986 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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