6Q3X
Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'(6'H)-one
Summary for 6Q3X
Entry DOI | 10.2210/pdb6q3x/pdb |
Related | 6Q3H |
Descriptor | Galactokinase, beta-D-galactopyranose, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total) |
Functional Keywords | ghmp kinase, galactose metabolism, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 86348.24 |
Authors | Bezerra, G.A.,Mackinnon, S.,Zhang, M.,Foster, W.,Bailey, H.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Lai, K.,Yue, W.W.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-04, release date: 2020-07-15, Last modification date: 2024-01-24) |
Primary citation | Mackinnon, S.R.,Krojer, T.,Foster, W.R.,Diaz-Saez, L.,Tang, M.,Huber, K.V.M.,von Delft, F.,Lai, K.,Brennan, P.E.,Arruda Bezerra, G.,Yue, W.W. Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. Acs Chem.Biol., 16:586-595, 2021 Cited by PubMed: 33724769DOI: 10.1021/acschembio.0c00498 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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