6Q39

Complex of Arginase 2 with Example 49

Summary for 6Q39

• Entry DOI: 10.2210/pdb6q39/pdb
• Related: 6Q37
• Descriptor: Arginase-2, mitochondrial, MANGANESE (II) ION, BENZAMIDINE, ... (6 entities in total)
• Functional Keywords: metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, mitochondrion, hydrolase-hydrolase inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 101610.08

Authors

Podjarny, A.D.,Van Zandt, M.C.,Cousido-Siah, A. (deposition date: 2018-12-03, release date: 2019-08-28, Last modification date: 2024-01-24)

• Primary citation: Van Zandt, M.C.,Jagdmann, G.E.,Whitehouse, D.L.,Ji, M.,Savoy, J.,Potapova, O.,Cousido-Siah, A.,Mitschler, A.,Howard, E.I.,Pyle, A.M.,Podjarny, A.D.; Discovery ofN-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.; J.Med.Chem., 62:8164-8177, 2019; PubMed: 31408339; DOI: 10.1021/acs.jmedchem.9b00931

Experimental method

X-RAY DIFFRACTION (2.213 Å)