6Q36

TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A resolution: Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence

6Q36 の概要

• エントリーDOI: 10.2210/pdb6q36/pdb
• 分子名称: Transcriptional enhancer factor TEF-3, ACE-PRO-6CW-ARG-LEU-ARG-LYS-2JH-HYP-ASP-SER-PHE-ALN-LYS-GLU-PRO-NH2, MYRISTIC ACID, ... (5 entities in total)
• 機能のキーワード: transcription factor, co-activator, transcription regulation, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56145.94

構造登録者

Kallen, J. (登録日: 2018-12-03, 公開日: 2019-07-03, 最終更新日: 2024-01-24)

• 主引用文献: Furet, P.,Salem, B.,Mesrouze, Y.,Schmelzle, T.,Lewis, I.,Kallen, J.,Chene, P.; Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.; Bioorg.Med.Chem.Lett., 29:2316-2319, 2019; PubMed: 31235263; DOI: 10.1016/j.bmcl.2019.06.022

実験手法

X-RAY DIFFRACTION (2.01 Å)