6Q2C

Domain-swapped dimer of Acanthamoeba castellanii CYP51

Summary for 6Q2C

Entry DOI	10.2210/pdb6q2c/pdb
Descriptor	Obtusifoliol 14alphademethylase, PROTOPORPHYRIN IX CONTAINING FE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	cyp51, ergosterol biosynthesis, acanthamoeba, 14-alpha-demethylase, oxidoreductase
Biological source	Acanthamoeba castellanii str. Neff
Total number of polymer chains	2
Total formula weight	106559.63
Authors	Sharma, V.,Podust, L.M. (deposition date: 2019-08-07, release date: 2020-10-21, Last modification date: 2023-10-11)
Primary citation	Sharma, V.,Shing, B.,Hernandez-Alvarez, L.,Debnath, A.,Podust, L.M. Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole. Mol.Pharmacol., 98:770-780, 2020 Cited by PubMed: 33008918 DOI: 10.1124/molpharm.120.000092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation