6Q1P

Glucocerebrosidase in complex with pharmacological chaperone norIMX8

6Q1P の概要

• エントリーDOI: 10.2210/pdb6q1p/pdb
• 分子名称: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: pharmacological chaperone, gaucher disease, glycosidase, inhibitor, pka, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116059.79

構造登録者

Vickers, C.,Withers, S.G.,Boraston, A.B. (登録日: 2019-08-05, 公開日: 2020-08-19, 最終更新日: 2024-11-06)

• 主引用文献: Santana, A.G.,Robinson, K.,Vickers, C.,Chen, H.,Zhou, S.,Boraston, A.B.,Clarke, L.A.,Withers, S.G.; Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models.; To Be Published,

実験手法

X-RAY DIFFRACTION (2.796 Å)