6PYY
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site and Exo site
Summary for 6PYY
| Entry DOI | 10.2210/pdb6pyy/pdb |
| Descriptor | Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, ... (4 entities in total) |
| Functional Keywords | tryptophan dioxygenase, pf-06840003, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 185053.77 |
| Authors | Pham, K.N.,Lewis-Ballester, A.,Yeh, S.R. (deposition date: 2019-07-31, release date: 2020-01-01, Last modification date: 2023-10-11) |
| Primary citation | Pham, K.N.,Lewis-Ballester, A.,Yeh, S.R. Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase. J.Am.Chem.Soc., 141:18771-18779, 2019 Cited by PubMed: 31682426DOI: 10.1021/jacs.9b08871 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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