6PYY

Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site and Exo site

6PYY の概要

• エントリーDOI: 10.2210/pdb6pyy/pdb
• 分子名称: Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, ... (4 entities in total)
• 機能のキーワード: tryptophan dioxygenase, pf-06840003, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 185053.77

構造登録者

Pham, K.N.,Lewis-Ballester, A.,Yeh, S.R. (登録日: 2019-07-31, 公開日: 2020-01-01, 最終更新日: 2023-10-11)

• 主引用文献: Pham, K.N.,Lewis-Ballester, A.,Yeh, S.R.; Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.; J.Am.Chem.Soc., 141:18771-18779, 2019; PubMed: 31682426; DOI: 10.1021/jacs.9b08871

実験手法

X-RAY DIFFRACTION (2.4 Å)