6PY8

Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA

Summary for 6PY8

• Entry DOI: 10.2210/pdb6py8/pdb
• Descriptor: Notch-regulated ankyrin repeat-containing protein, DNA, Recombining binding protein suppressor of hairless, ... (5 entities in total)
• Functional Keywords: notch1, nrarp, rbpj, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 226373.81

Authors

Jarrett, S.M.,Seegar, T.C.M.,Blacklow, S.C. (deposition date: 2019-07-29, release date: 2019-08-14, Last modification date: 2023-10-11)

• Primary citation: Jarrett, S.M.,Seegar, T.C.M.,Andrews, M.,Adelmant, G.,Marto, J.A.,Aster, J.C.,Blacklow, S.C.; Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.; Sci.Signal., 12:-, 2019; PubMed: 31690634; DOI: 10.1126/scisignal.aay2369

Experimental method

X-RAY DIFFRACTION (3.75 Å)