6PXA
The crystal structure of chloramphenicol acetyltransferase-like protein from Vibrio fischeri ES114 in complex with taurocholic acid
Summary for 6PXA
| Entry DOI | 10.2210/pdb6pxa/pdb |
| Related | 5UX9 |
| Descriptor | Chloramphenicol acetyltransferase, TAUROCHOLIC ACID, CHLORIDE ION, ... (8 entities in total) |
| Functional Keywords | structural genomics, center for structural genomics of infectious diseases, csgid, transferase |
| Biological source | Aliivibrio fischeri (strain ATCC 700601 / ES114) |
| Total number of polymer chains | 12 |
| Total formula weight | 305234.92 |
| Authors | Tan, K.,Maltseva, N.,Jedrzejczak, R.,Kuhn, M.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2019-07-25, release date: 2019-09-25, Last modification date: 2025-06-18) |
| Primary citation | Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F. Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria. Microbiol Resour Announc, :e0020025-e0020025, 2025 Cited by PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications. PubMed: 40391899DOI: 10.1128/mra.00200-25 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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