6PVW

RNase A in complex with cp4pA

Summary for 6PVW

Entry DOI	10.2210/pdb6pvw/pdb
Descriptor	Ribonuclease pancreatic, 5'-O-[(R)-hydroxy{[(4R,8S)-4,6,8-trihydroxy-2,4,6,8-tetraoxo-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~-tetroxatetraphosphocan-2-yl]oxy}phosphoryl]adenosine, 2,4,6,8-tetrahydroxy-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~-tetroxatetraphosphocane-2,4,6,8-tetrone, ... (4 entities in total)
Functional Keywords	rnase a, nucleotide, poly-phosphate, metaphosphate, lyase
Biological source	Bos taurus (Bovine)
Total number of polymer chains	2
Total formula weight	28385.70
Authors	Windsor, I.W.,Sheppard, S.M.,Cummins, C.C.,Raines, R.T. (deposition date: 2019-07-21, release date: 2019-11-06, Last modification date: 2023-10-11)
Primary citation	Shepard, S.M.,Windsor, I.W.,Raines, R.T.,Cummins, C.C. Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A. J.Am.Chem.Soc., 141:18400-18404, 2019 Cited by PubMed: 31651164 DOI: 10.1021/jacs.9b09760 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation