6PT3

Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287

6PT3 の概要

• エントリーDOI: 10.2210/pdb6pt3/pdb
• 分子名称: Delta opioid receptor, 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide (2 entities in total)
• 機能のキーワード: membrane protein, g protein-coupled receptor, gpcr, dop, dor, agonist, active dop-dpi-287 structure, lcp, membrane protein-agonist complex, membrane protein/agonist
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103089.52

構造登録者

Claff, T.,Yu, J.,Blais, V.,Patel, N.,Martin, C.,Wu, L.,Han, G.W.,Holleran, B.J.,Van der Poorten, O.,Hanson, M.A.,Sarret, P.,Gendron, L.,Cherezov, V.,Katritch, V.,Ballet, S.,Liu, Z.,Muller, C.E.,Stevens, R.C. (登録日: 2019-07-14, 公開日: 2019-12-11, 最終更新日: 2023-10-11)

• 主引用文献: Claff, T.,Yu, J.,Blais, V.,Patel, N.,Martin, C.,Wu, L.,Han, G.W.,Holleran, B.J.,Van der Poorten, O.,White, K.L.,Hanson, M.A.,Sarret, P.,Gendron, L.,Cherezov, V.,Katritch, V.,Ballet, S.,Liu, Z.J.,Muller, C.E.,Stevens, R.C.; Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists.; Sci Adv, 5:eaax9115-eaax9115, 2019; PubMed: 31807708; DOI: 10.1126/sciadv.aax9115

実験手法

X-RAY DIFFRACTION (3.3 Å)