Crystal structure of NeuB, an N-acetylneuraminate synthase from Neisseria meningitidis, in complex with magnesium and malate

Replaces:  2ZDR

Summary for 6PPW

DescriptorN-acetylneuraminate synthase, MAGNESIUM ION, D-MALATE, ... (4 entities in total)
Functional Keywordsneub, transferase, sialic acid synthase, n-acetylneuraminate synthase, biosynthetic protein
Biological sourceNeisseria meningitidis serogroup B
Total number of polymer chains1
Total molecular weight38554.12
Rosanally, A.Z.,Junop, M.S.,Berti, P.J. (deposition date: 2019-07-08, release date: 2019-10-02, Last modification date: 2020-01-08)
Primary citation
Popovic, V.,Morrison, E.,Rosanally, A.Z.,Balachandran, N.,Senson, A.W.,Szabla, R.,Junop, M.S.,Berti, P.J.
NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB.
Biochemistry, 58:4236-4245, 2019
PubMed: 31549502 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.9b00654
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.223200 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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