6PPW

Crystal structure of NeuB, an N-acetylneuraminate synthase from Neisseria meningitidis, in complex with magnesium and malate

Replaces:  2ZDR

Summary for 6PPW

• Entry DOI: 10.2210/pdb6ppw/pdb
• Descriptor: N-acetylneuraminate synthase, MAGNESIUM ION, D-MALATE, ... (4 entities in total)
• Functional Keywords: neub, transferase, sialic acid synthase, n-acetylneuraminate synthase, biosynthetic protein
• Biological source: Neisseria meningitidis serogroup B
• Total number of polymer chains: 1
• Total formula weight: 38554.12

Authors

Rosanally, A.Z.,Junop, M.S.,Berti, P.J. (deposition date: 2019-07-08, release date: 2019-10-02, Last modification date: 2023-10-11)

• Primary citation: Popovic, V.,Morrison, E.,Rosanally, A.Z.,Balachandran, N.,Senson, A.W.,Szabla, R.,Junop, M.S.,Berti, P.J.; NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB.; Biochemistry, 58:4236-4245, 2019; PubMed: 31549502; DOI: 10.1021/acs.biochem.9b00654

Experimental method

X-RAY DIFFRACTION (1.85 Å)