6PPM

Ancestral Caspase 6

Summary for 6PPM

• Entry DOI: 10.2210/pdb6ppm/pdb
• Related: 6PDQ
• Descriptor: Ancestral Caspase-6 Large Subunit, Ancestral Caspase-6 small subunit, VAL-GLU-ILE-ASP Inhibitor, ... (4 entities in total)
• Functional Keywords: ancestral effector caspase, protease, ancestral protein reconstruction, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 115588.16

Authors

Clark, A.C. (deposition date: 2019-07-08, release date: 2019-11-13, Last modification date: 2023-10-11)

• Primary citation: Grinshpon, R.D.,Shrestha, S.,Titus-McQuillan, J.,Hamilton, P.T.,Swartz, P.D.,Clark, A.C.; Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity.; Biochem.J., 476:3475-3492, 2019; PubMed: 31675069; DOI: 10.1042/BCJ20190625

Experimental method

X-RAY DIFFRACTION (2.61 Å)