6PO8
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-((4-(2-Amino-4-methylquinolin-7-yl)-2-(aminomethyl)phenoxy)methyl)benzonitrile
Summary for 6PO8
Entry DOI | 10.2210/pdb6po8/pdb |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 100138.81 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2019-07-03, release date: 2020-04-29, Last modification date: 2023-10-11) |
Primary citation | Cinelli, M.A.,Reidl, C.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63:4528-4554, 2020 Cited by PubMed: 32302123DOI: 10.1021/acs.jmedchem.9b01573 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.898 Å) |
Structure validation
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