6PO8

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-((4-(2-Amino-4-methylquinolin-7-yl)-2-(aminomethyl)phenoxy)methyl)benzonitrile

Summary for 6PO8

Entry DOI	10.2210/pdb6po8/pdb
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywords	nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	100138.81
Authors	Li, H.,Poulos, T.L. (deposition date: 2019-07-03, release date: 2020-04-29, Last modification date: 2023-10-11)
Primary citation	Cinelli, M.A.,Reidl, C.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63:4528-4554, 2020 Cited by PubMed: 32302123 DOI: 10.1021/acs.jmedchem.9b01573 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.898 Å)

Structure validation