6PNN

Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)acetamide

Summary for 6PNN

Entry DOI	10.2210/pdb6pnn/pdb
Descriptor	Glutathione S-transferase omega-1, SULFATE ION, L(+)-TARTARIC ACID, ... (5 entities in total)
Functional Keywords	glutathione transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28166.10
Authors	Oakley, A.J. (deposition date: 2019-07-02, release date: 2019-07-24, Last modification date: 2023-10-11)
Primary citation	Xie, Y.,Tummala, P.,Oakley, A.J.,Deora, G.S.,Nakano, Y.,Rooke, M.,Cuellar, M.E.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Casarotto, M.G.,Board, P.G.,Baell, J.B. Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors. J.Med.Chem., 63:2894-2914, 2020 Cited by PubMed: 32105470 DOI: 10.1021/acs.jmedchem.9b01391 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation