6PN0

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(3-(Aminomethyl)-4-ethoxyphenyl)-4-methylquinolin-2-amine

Summary for 6PN0

Entry DOI	10.2210/pdb6pn0/pdb
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	2
Total formula weight	100138.80
Authors	Li, H.,Poulos, T.L. (deposition date: 2019-07-02, release date: 2020-04-29, Last modification date: 2023-10-11)
Primary citation	Cinelli, M.A.,Reidl, C.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63:4528-4554, 2020 Cited by PubMed: 32302123 DOI: 10.1021/acs.jmedchem.9b01573 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.229 Å)

Structure validation