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6PJH

HIV-1 Protease NL4-3 WT in Complex with LR3-28

Summary for 6PJH
Entry DOI10.2210/pdb6pjh/pdb
DescriptorProtease NL4-3, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,4S,5S)-4-hydroxy-5-{[N-(methoxycarbonyl)-L-valyl]amino}-1,6-diphenylhexan-2-yl]carbamate, SULFATE ION, ... (4 entities in total)
Functional Keywordshiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22549.55
Authors
Lockbaum, G.J.,Rusere, L.N.,Henes, M.,Kosovrasti, K.,Lee, S.K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,KurtYilmaz, N.,Schiffer, C.A.,Ali, A. (deposition date: 2019-06-28, release date: 2020-07-01, Last modification date: 2023-10-11)
Primary citationRusere, L.N.,Lockbaum, G.J.,Henes, M.,Lee, S.K.,Spielvogel, E.,Rao, D.N.,Kosovrasti, K.,Nalivaika, E.A.,Swanstrom, R.,Kurt Yilmaz, N.,Schiffer, C.A.,Ali, A.
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
J.Med.Chem., 63:8296-8313, 2020
Cited by
PubMed: 32672965
DOI: 10.1021/acs.jmedchem.0c00529
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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