6PH9
Crystal Structure of the Klebsiella pneumoniae LpxH-lipid X complex
Summary for 6PH9
Entry DOI | 10.2210/pdb6ph9/pdb |
Descriptor | UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, ... (7 entities in total) |
Functional Keywords | lipid a, lpxh, lipid x, biosynthetic protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 31149.02 |
Authors | |
Primary citation | Cho, J.,Lee, M.,Cochrane, C.S.,Webster, C.G.,Fenton, B.A.,Zhao, J.,Hong, J.,Zhou, P. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117:4109-4116, 2020 Cited by PubMed: 32041866DOI: 10.1073/pnas.1912876117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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