6PF5
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic acid
Summary for 6PF5
Entry DOI | 10.2210/pdb6pf5/pdb |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid, ... (4 entities in total) |
Functional Keywords | inhibitor, ts, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 135778.78 |
Authors | Czyzyk, D.J.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2019-06-21, release date: 2019-10-02, Last modification date: 2023-10-11) |
Primary citation | Czyzyk, D.J.,Valhondo, M.,Deiana, L.,Tirado-Rives, J.,Jorgensen, W.L.,Anderson, K.S. Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183:111673-111673, 2019 Cited by PubMed: 31536894DOI: 10.1016/j.ejmech.2019.111673 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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