6PF5
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Thymidylate synthase | polymer | 290 | 33189.1 | 4 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (Human) | TSase |
| 2 | E, G, I, K (A, B, C, D) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
| 3 | F, H, J, L (A, B, C, D) | [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid | non-polymer | 447.4 | 4 | Chemie (OED) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| - | Glu 7 | deletion |
| - | Leu 8 | deletion |
| - | Pro 9 | deletion |
| - | Arg 10 | deletion |
| - | Arg 11 | deletion |
| - | Pro 12 | deletion |
| - | Leu 13 | deletion |
| - | Pro 14 | deletion |
| - | Pro 15 | deletion |
| - | Ala 16 | deletion |
| - | Ala 17 | deletion |
| - | Gln 18 | deletion |
| - | Glu 19 | deletion |
| - | Arg 20 | deletion |
| - | Asp 21 | deletion |
| - | Ala 22 | deletion |
| - | Glu 23 | deletion |
| - | Pro 24 | deletion |
| - | Arg 25 | deletion |
| - | Pro 26 | deletion |
| - | Pro 27 | deletion |
| - | His 28 | deletion |
| - | Gly 29 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 132756.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3022.5 | |
| All* | Total formula weight | 135778.8 |
