6PEB
Crystal Structure of human NAMPT in complex with NVP-LTM976
Summary for 6PEB
Entry DOI | 10.2210/pdb6peb/pdb |
Related | 6ATB |
Descriptor | Nicotinamide phosphoribosyltransferase, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-3-(pyridin-3-yl)azetidine-1-carboxamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 229621.70 |
Authors | Weihofen, W.A. (deposition date: 2019-06-20, release date: 2019-12-04, Last modification date: 2023-10-11) |
Primary citation | Palacios, D.S.,Meredith, E.L.,Kawanami, T.,Adams, C.M.,Chen, X.,Darsigny, V.,Palermo, M.,Baird, D.,George, E.L.,Guy, C.,Hewett, J.,Tierney, L.,Thigale, S.,Wang, L.,Weihofen, W.A. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT). Acs Med.Chem.Lett., 10:1524-1529, 2019 Cited by PubMed: 31749905DOI: 10.1021/acsmedchemlett.9b00325 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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