6PDJ

Tyrosine-protein kinase LCK bound to Compound 11

Summary for 6PDJ

• Entry DOI: 10.2210/pdb6pdj/pdb
• Descriptor: Tyrosine-protein kinase Lck, N-{4-[(6-methoxypyrazolo[1,5-a]pyridine-3-carbonyl)amino]-3-methylphenyl}-1-methyl-1H-indazole-3-carboxamide, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... (6 entities in total)
• Functional Keywords: inhibitor, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 34318.61

Authors

Critton, D.A. (deposition date: 2019-06-19, release date: 2019-10-09, Last modification date: 2023-11-15)

• Primary citation: O'Malley, D.P.,Ahuja, V.,Fink, B.,Cao, C.,Wang, C.,Swanson, J.,Wee, S.,Gavai, A.V.,Tokarski, J.,Critton, D.,Paiva, A.A.,Johnson, B.M.,Szapiel, N.,Xie, D.; Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.; Acs Med.Chem.Lett., 10:1486-1491, 2019; PubMed: 31620238; DOI: 10.1021/acsmedchemlett.9b00354

Experimental method

X-RAY DIFFRACTION (1.81 Å)