6PBF

ZINC9155420-bound TRPV5 in nanodiscs

6PBF の概要

• エントリーDOI: 10.2210/pdb6pbf/pdb
• EMDBエントリー: 20291 20292
• 分子名称: Transient receptor potential cation channel subfamily V member 5, (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate (2 entities in total)
• 機能のキーワード: trpv5, trp channel, inhibitor, calcium channel, transport protein
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 333508.84

構造登録者

Hughes, T.E.T.,Rosario, J.S.D.,Kapoor, A.,Yazici, A.T.,Fluck, E.C.,Filizola, M.,Rohacs, T.,Moiseenkova-Bell, V.Y. (登録日: 2019-06-13, 公開日: 2019-11-06, 最終更新日: 2024-03-20)

• 主引用文献: Hughes, T.E.,Del Rosario, J.S.,Kapoor, A.,Yazici, A.T.,Yudin, Y.,Fluck, E.C.,Filizola, M.,Rohacs, T.,Moiseenkova-Bell, V.Y.; Structure-based characterization of novel TRPV5 inhibitors.; Elife, 8:-, 2019; PubMed: 31647410; DOI: 10.7554/eLife.49572

実験手法

ELECTRON MICROSCOPY (4.2 Å)