6PBE

ZINC17988990-bound TRPV5 in nanodiscs

Summary for 6PBE

Entry DOI	10.2210/pdb6pbe/pdb
EMDB information	20291 20292
Descriptor	Transient receptor potential cation channel subfamily V member 5, (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate (2 entities in total)
Functional Keywords	trpv5, trp channel, inhibitor, calcium channel, transport protein
Biological source	Oryctolagus cuniculus (Rabbit)
Total number of polymer chains	4
Total formula weight	335290.54
Authors	Hughes, T.E.T.,Rosario, J.S.D.,Kapoor, A.,Yazici, A.T.,Fluck, E.C.,Filizola, M.,Rohacs, T.,Moiseenkova-Bell, V.Y. (deposition date: 2019-06-13, release date: 2019-11-06, Last modification date: 2024-03-20)
Primary citation	Hughes, T.E.,Del Rosario, J.S.,Kapoor, A.,Yazici, A.T.,Yudin, Y.,Fluck, E.C.,Filizola, M.,Rohacs, T.,Moiseenkova-Bell, V.Y. Structure-based characterization of novel TRPV5 inhibitors. Elife, 8:-, 2019 Cited by PubMed: 31647410 DOI: 10.7554/eLife.49572 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.78 Å)

Structure validation