6PBE
ZINC17988990-bound TRPV5 in nanodiscs
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005262 | molecular_function | calcium channel activity |
A | 0005516 | molecular_function | calmodulin binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006816 | biological_process | calcium ion transport |
A | 0016020 | cellular_component | membrane |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0035809 | biological_process | regulation of urine volume |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051289 | biological_process | protein homotetramerization |
A | 0055074 | biological_process | calcium ion homeostasis |
A | 0055085 | biological_process | transmembrane transport |
A | 0070588 | biological_process | calcium ion transmembrane transport |
A | 0098655 | biological_process | monoatomic cation transmembrane transport |
A | 0098703 | biological_process | calcium ion import across plasma membrane |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005262 | molecular_function | calcium channel activity |
B | 0005516 | molecular_function | calmodulin binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006816 | biological_process | calcium ion transport |
B | 0016020 | cellular_component | membrane |
B | 0016324 | cellular_component | apical plasma membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0035809 | biological_process | regulation of urine volume |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051289 | biological_process | protein homotetramerization |
B | 0055074 | biological_process | calcium ion homeostasis |
B | 0055085 | biological_process | transmembrane transport |
B | 0070588 | biological_process | calcium ion transmembrane transport |
B | 0098655 | biological_process | monoatomic cation transmembrane transport |
B | 0098703 | biological_process | calcium ion import across plasma membrane |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005262 | molecular_function | calcium channel activity |
C | 0005516 | molecular_function | calmodulin binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0006816 | biological_process | calcium ion transport |
C | 0016020 | cellular_component | membrane |
C | 0016324 | cellular_component | apical plasma membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0035809 | biological_process | regulation of urine volume |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0051289 | biological_process | protein homotetramerization |
C | 0055074 | biological_process | calcium ion homeostasis |
C | 0055085 | biological_process | transmembrane transport |
C | 0070588 | biological_process | calcium ion transmembrane transport |
C | 0098655 | biological_process | monoatomic cation transmembrane transport |
C | 0098703 | biological_process | calcium ion import across plasma membrane |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005262 | molecular_function | calcium channel activity |
D | 0005516 | molecular_function | calmodulin binding |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0006816 | biological_process | calcium ion transport |
D | 0016020 | cellular_component | membrane |
D | 0016324 | cellular_component | apical plasma membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0035809 | biological_process | regulation of urine volume |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0051289 | biological_process | protein homotetramerization |
D | 0055074 | biological_process | calcium ion homeostasis |
D | 0055085 | biological_process | transmembrane transport |
D | 0070588 | biological_process | calcium ion transmembrane transport |
D | 0098655 | biological_process | monoatomic cation transmembrane transport |
D | 0098703 | biological_process | calcium ion import across plasma membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | binding site for residue O6S A 1001 |
Chain | Residue |
A | LEU402 |
A | MET603 |
A | ARG606 |
A | GLU403 |
A | ASP406 |
A | TYR415 |
A | LEU421 |
A | HIS426 |
A | ILE429 |
A | TYR467 |
A | PHE468 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue O6S A 1002 |
Chain | Residue |
A | PHE487 |
A | LEU490 |
A | MET491 |
A | CYS494 |
A | TRP495 |
C | ILE565 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue O6S B 1001 |
Chain | Residue |
B | LEU402 |
B | GLU403 |
B | ASP406 |
B | TYR415 |
B | LEU421 |
B | HIS426 |
B | ILE429 |
B | TYR467 |
B | PHE468 |
B | MET603 |
B | ARG606 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue O6S B 1002 |
Chain | Residue |
A | ILE565 |
B | PHE487 |
B | LEU490 |
B | MET491 |
B | CYS494 |
B | TRP495 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue O6S C 1001 |
Chain | Residue |
C | LEU402 |
C | GLU403 |
C | ASP406 |
C | TYR415 |
C | LEU421 |
C | HIS426 |
C | ILE429 |
C | TYR467 |
C | PHE468 |
C | MET603 |
C | ARG606 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue O6S C 1002 |
Chain | Residue |
C | PHE487 |
C | LEU490 |
C | MET491 |
C | CYS494 |
C | TRP495 |
D | ILE565 |
site_id | AC7 |
Number of Residues | 11 |
Details | binding site for residue O6S D 1001 |
Chain | Residue |
D | LEU402 |
D | GLU403 |
D | ASP406 |
D | TYR415 |
D | LEU421 |
D | HIS426 |
D | ILE429 |
D | TYR467 |
D | PHE468 |
D | MET603 |
D | ARG606 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue O6S D 1002 |
Chain | Residue |
B | ILE565 |
D | PHE487 |
D | LEU490 |
D | MET491 |
D | CYS494 |
D | TRP495 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2040 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29323279 |
Chain | Residue | Details |
A | MET1-PRO327 | |
C | ARG409-THR419 | |
C | ARG470-ARG492 | |
C | MET578-PHE730 | |
D | MET1-PRO327 | |
D | ARG409-THR419 | |
D | ARG470-ARG492 | |
D | MET578-PHE730 | |
A | ARG409-THR419 | |
A | ARG470-ARG492 | |
A | MET578-PHE730 | |
B | MET1-PRO327 | |
B | ARG409-THR419 | |
B | ARG470-ARG492 | |
B | MET578-PHE730 | |
C | MET1-PRO327 |
site_id | SWS_FT_FI2 |
Number of Residues | 496 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:29323279 |
Chain | Residue | Details |
A | TYR328-ILE348 | |
B | GLY449-ALA469 | |
B | PHE493-GLN513 | |
B | ILE557-MET577 | |
C | TYR328-ILE348 | |
C | LEU386-PHE408 | |
C | ILE420-MET442 | |
C | GLY449-ALA469 | |
C | PHE493-GLN513 | |
C | ILE557-MET577 | |
D | TYR328-ILE348 | |
A | LEU386-PHE408 | |
D | LEU386-PHE408 | |
D | ILE420-MET442 | |
D | GLY449-ALA469 | |
D | PHE493-GLN513 | |
D | ILE557-MET577 | |
A | ILE420-MET442 | |
A | GLY449-ALA469 | |
A | PHE493-GLN513 | |
A | ILE557-MET577 | |
B | TYR328-ILE348 | |
B | LEU386-PHE408 | |
B | ILE420-MET442 |
site_id | SWS_FT_FI3 |
Number of Residues | 164 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:29323279 |
Chain | Residue | Details |
A | TYR349-ARG385 | |
A | ARG443-ASN448 | |
B | TYR349-ARG385 | |
B | ARG443-ASN448 | |
C | TYR349-ARG385 | |
C | ARG443-ASN448 | |
D | TYR349-ARG385 | |
D | ARG443-ASN448 |
site_id | SWS_FT_FI4 |
Number of Residues | 80 |
Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:29323279 |
Chain | Residue | Details |
A | SER524-PRO544 | |
B | SER524-PRO544 | |
C | SER524-PRO544 | |
D | SER524-PRO544 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29323279 |
Chain | Residue | Details |
A | ASP542 | |
B | ASP542 | |
C | ASP542 | |
D | ASP542 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P69744 |
Chain | Residue | Details |
A | THR685 | |
B | THR685 | |
C | THR685 | |
D | THR685 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P69744 |
Chain | Residue | Details |
A | SER689 | |
B | SER689 | |
C | SER689 | |
D | SER689 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN358 | |
B | ASN358 | |
C | ASN358 | |
D | ASN358 |