6PB0
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35
Summary for 6PB0
Entry DOI | 10.2210/pdb6pb0/pdb |
EMDB information | 20284 |
Descriptor | Corticotropin-releasing factor receptor 1, Urocortin, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (8 entities in total) |
Functional Keywords | corticotropin-releasing factor 1 receptor, urocortins1, gs protein, gpcr, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 156958.67 |
Authors | Ma, S.,Shen, Q.,Zhao, L.-H.,Mao, C.,Zhou, X.E.,Shen, D.-D.,de Waal, P.W.,Bi, P.,Li, C.,Jiang, Y.,Wang, M.-W.,Sexton, P.M.,Wootten, D.,Melcher, K.,Zhang, Y.,Xu, H.E. (deposition date: 2019-06-12, release date: 2020-02-12, Last modification date: 2020-02-19) |
Primary citation | Ma, S.,Shen, Q.,Zhao, L.H.,Mao, C.,Zhou, X.E.,Shen, D.D.,de Waal, P.W.,Bi, P.,Li, C.,Jiang, Y.,Wang, M.W.,Sexton, P.M.,Wootten, D.,Melcher, K.,Zhang, Y.,Xu, H.E. Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol.Cell, 77:669-, 2020 Cited by PubMed: 32004470DOI: 10.1016/j.molcel.2020.01.013 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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