6PB0

Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35

6PB0 の概要

• エントリーDOI: 10.2210/pdb6pb0/pdb
• EMDBエントリー: 20284
• 分子名称: Corticotropin-releasing factor receptor 1, Urocortin, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (8 entities in total)
• 機能のキーワード: corticotropin-releasing factor 1 receptor, urocortins1, gs protein, gpcr, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 156958.67

構造登録者

Ma, S.,Shen, Q.,Zhao, L.-H.,Mao, C.,Zhou, X.E.,Shen, D.-D.,de Waal, P.W.,Bi, P.,Li, C.,Jiang, Y.,Wang, M.-W.,Sexton, P.M.,Wootten, D.,Melcher, K.,Zhang, Y.,Xu, H.E. (登録日: 2019-06-12, 公開日: 2020-02-12, 最終更新日: 2020-02-19)

• 主引用文献: Ma, S.,Shen, Q.,Zhao, L.H.,Mao, C.,Zhou, X.E.,Shen, D.D.,de Waal, P.W.,Bi, P.,Li, C.,Jiang, Y.,Wang, M.W.,Sexton, P.M.,Wootten, D.,Melcher, K.,Zhang, Y.,Xu, H.E.; Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.; Mol.Cell, 77:669-, 2020; PubMed: 32004470; DOI: 10.1016/j.molcel.2020.01.013

実験手法

ELECTRON MICROSCOPY (3 Å)