6P9Q

E.coli LpxA in complex with UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc and Compound 2

Summary for 6P9Q

• Entry DOI: 10.2210/pdb6p9q/pdb
• Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: acyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 30566.36

Authors

Ma, X.,Shia, S.,Ornelas, E. (deposition date: 2019-06-10, release date: 2020-03-11, Last modification date: 2023-10-11)

• Primary citation: Han, W.,Ma, X.,Balibar, C.J.,Baxter Rath, C.M.,Benton, B.,Bermingham, A.,Casey, F.,Chie-Leon, B.,Cho, M.K.,Frank, A.O.,Frommlet, A.,Ho, C.M.,Lee, P.S.,Li, M.,Lingel, A.,Ma, S.,Merritt, H.,Ornelas, E.,De Pascale, G.,Prathapam, R.,Prosen, K.R.,Rasper, D.,Ruzin, A.,Sawyer, W.S.,Shaul, J.,Shen, X.,Shia, S.,Steffek, M.,Subramanian, S.,Vo, J.,Wang, F.,Wartchow, C.,Uehara, T.; Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.; J.Am.Chem.Soc., 142:4445-4455, 2020; PubMed: 32064871; DOI: 10.1021/jacs.9b13530

Experimental method

X-RAY DIFFRACTION (1.7 Å)