6P9A
HIV-1 Protease multiple mutant PRS5B with Darunavir
Summary for 6P9A
Entry DOI | 10.2210/pdb6p9a/pdb |
Related | 2IEN |
Descriptor | HIV-1 Protease, PHOSPHATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total) |
Functional Keywords | protease, inhibitor, multiple mutant, hydrolase-hydrolase inhibitor, viral protein complex, hydrolase/hydrolase inhibitor, viral protein |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22368.66 |
Authors | Kneller, D.W.,Agniswamy, J.,Weber, I.T. (deposition date: 2019-06-10, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Kneller, D.W.,Agniswamy, J.,Harrison, R.W.,Weber, I.T. Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations. Febs J., 287:3235-3254, 2020 Cited by PubMed: 31920003DOI: 10.1111/febs.15207 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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