6P8E

Crystal structure of CDK4 in complex with CyclinD1 and P27

Summary for 6P8E

• Entry DOI: 10.2210/pdb6p8e/pdb
• Descriptor: G1/S-specific cyclin-D1, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, ... (5 entities in total)
• Functional Keywords: cyclin-dependent kinase, kinase inhibitor, cell cycle, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 71214.56

Authors

Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Bunch, K.,Tripathi, S.M.,Shokat, K.M.,Rubin, S.M. (deposition date: 2019-06-07, release date: 2019-12-25, Last modification date: 2024-03-13)

• Primary citation: Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Kumarasamy, V.,Wijeratne, T.U.,Bunch, K.L.,Tripathi, S.,Knudsen, E.S.,Witkiewicz, A.K.,Shokat, K.M.,Rubin, S.M.; p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.; Science, 366:-, 2019; PubMed: 31831640; DOI: 10.1126/science.aaw2106

Experimental method

X-RAY DIFFRACTION (2.3 Å)