6P78

queuine lyase from Clostridium spiroforme bound to SAM and queuine

6P78 の概要

• エントリーDOI: 10.2210/pdb6p78/pdb
• 分子名称: Queuine lyase, IRON/SULFUR CLUSTER, 2-amino-5-({[(1S,4S,5S)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, ... (5 entities in total)
• 機能のキーワード: metal ion binding, 4 iron 4 sulfur cluster binding, radical sam enzyme, c-n lyase activity, lyase
• 由来する生物種: [Clostridium] spiroforme DSM 1552
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30961.44

構造登録者

Almo, S.C.,Grove, T.L. (登録日: 2019-06-05, 公開日: 2019-09-18, 最終更新日: 2019-12-18)

• 主引用文献: Yuan, Y.,Zallot, R.,Grove, T.L.,Payan, D.J.,Martin-Verstraete, I.,Sepic, S.,Balamkundu, S.,Neelakandan, R.,Gadi, V.K.,Liu, C.F.,Swairjo, M.A.,Dedon, P.C.,Almo, S.C.,Gerlt, J.A.,de Crecy-Lagard, V.; Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.; Proc.Natl.Acad.Sci.USA, 116:19126-19135, 2019; PubMed: 31481610; DOI: 10.1073/pnas.1909604116

実験手法

X-RAY DIFFRACTION (1.726 Å)