6P6V

HCV NS3/4A protease domain of genotype 5a in complex with glecaprevir

6P6V の概要

• エントリーDOI: 10.2210/pdb6p6v/pdb
• 分子名称: Non-structural protein 4A,Serine protease NS3, ZINC ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: hcv ns3/4a protease hcv protease domain glecaprevir, gle genotype 1a3a chimera, viral protein, hydrolase
• 由来する生物種: Hepatitis C virus genotype 5a (isolate SA13) (HCV); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22372.21

構造登録者

Timm, J.,Schiffer, C.A. (登録日: 2019-06-04, 公開日: 2020-06-10, 最終更新日: 2023-10-11)

• 主引用文献: Timm, J.,Kosovrasti, K.,Henes, M.,Leidner, F.,Hou, S.,Kurt-Yilmaz, N.,Schiffer, C.A.; Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences; To Be Published,

実験手法

X-RAY DIFFRACTION (2 Å)