6P5S
HIPK2 kinase domain bound to CX-4945
Summary for 6P5S
Entry DOI | 10.2210/pdb6p5s/pdb |
Descriptor | Homeodomain-interacting protein kinase 2, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (3 entities in total) |
Functional Keywords | homeodomain interacting protein, kinase, p53 regulator, mitophagy, fibrosis, nuclear protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 45326.82 |
Authors | |
Primary citation | Agnew, C.,Liu, L.,Liu, S.,Xu, W.,You, L.,Yeung, W.,Kannan, N.,Jablons, D.,Jura, N. The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region. J.Biol.Chem., 294:13545-13559, 2019 Cited by PubMed: 31341017DOI: 10.1074/jbc.RA119.009725 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.194 Å) |
Structure validation
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