6P24
Escherichia coli tRNA synthetase
Summary for 6P24
Entry DOI | 10.2210/pdb6p24/pdb |
Descriptor | Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, MAGNESIUM ION, ... (10 entities in total) |
Functional Keywords | inhibitor, aminoacyl-trna synthetase, phers, antibacterial, ligase |
Biological source | Escherichia coli (strain K12) More |
Total number of polymer chains | 4 |
Total formula weight | 253449.95 |
Authors | Kahne, D.,Baidin, V.,Owens, T.W. (deposition date: 2019-05-20, release date: 2020-11-18, Last modification date: 2023-10-11) |
Primary citation | Baidin, V.,Owens, T.W.,Lazarus, M.B.,Kahne, D. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143:623-627, 2021 Cited by PubMed: 33411531DOI: 10.1021/jacs.0c11113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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