6OZ4

Crystal structure of broadly neutralizing antibody N49P6 Fab in complex with HIV-1 BG505 SOSIP.664 Env trimer ectodomain.

6OZ4 の概要

• エントリーDOI: 10.2210/pdb6oz4/pdb
• 分子名称: Envelope glycoprotein gp160, Envelope glycoprotein gp41, N49P6 antibody Fab heavy chain, ... (9 entities in total)
• 機能のキーワード: hiv-1 envelop trimer, gp120, gp41, viral entry, viral protein-immune system complex, type-1 membrane fusion glycoprotein, n49p6, immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126169.42

構造登録者

Tolbert, W.D.,Pazgier, M. (登録日: 2019-05-15, 公開日: 2020-08-19, 最終更新日: 2023-10-11)

• 主引用文献: Tolbert, W.D.,Nguyen, D.N.,Tehrani, Z.R.,Sajadi, M.M.,Pazgier, M.; Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer.; Mbio, :e0127421-e0127421, 2021; PubMed: 34281393; DOI: 10.1128/mBio.01274-21

実験手法

X-RAY DIFFRACTION (4.05 Å)