6OYZ

Crystal structure of MraY bound to capuramycin

Summary for 6OYZ

• Entry DOI: 10.2210/pdb6oyz/pdb
• Descriptor: MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (2~{S},3~{S},4~{S})-2-[(1~{R})-2-azanyl-1-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-methoxy-4-oxidanyl-oxolan-2-yl]-2-oxidanylidene-ethoxy]-3,4-bis(oxidanyl)-~{N}-[(3~{S})-2-oxidanylideneazepan-3-yl]-3,4-dihydro-2~{H}-pyran-6-carboxamide (3 entities in total)
• Functional Keywords: peptidoglycan biosynthesis, antibiotic target, integral membrane enzyme, translocase, membrane protein/transferase, membrane protein, membrane protein-transferase complex
• Biological source: Lama glama; More
• Total number of polymer chains: 8
• Total formula weight: 224618.86

Authors

Mashalidis, E.H.,Lee, S.Y. (deposition date: 2019-05-15, release date: 2019-07-10, Last modification date: 2023-10-11)

• Primary citation: Mashalidis, E.H.,Kaeser, B.,Terasawa, Y.,Katsuyama, A.,Kwon, D.Y.,Lee, K.,Hong, J.,Ichikawa, S.,Lee, S.Y.; Chemical logic of MraY inhibition by antibacterial nucleoside natural products.; Nat Commun, 10:2917-2917, 2019; PubMed: 31266949; DOI: 10.1038/s41467-019-10957-9

Experimental method

X-RAY DIFFRACTION (3.62 Å)