6OYD
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-004
Summary for 6OYD
Entry DOI | 10.2210/pdb6oyd/pdb |
Descriptor | Protease, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl {(2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-[(2-methylpropyl)({2-[(propan-2-yl)amino]-1,3-benzoxazol-6-yl}sulfonyl)amino]butan-2-yl}carbamate (3 entities in total) |
Functional Keywords | inhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 11505.56 |
Authors | Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2019-05-14, release date: 2020-05-20, Last modification date: 2023-10-11) |
Primary citation | Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Das, D.,Aoki, M.,Davis, D.A.,Rao, K.V.,Nyalapatla, P.R.,Ghosh, A.K.,Mitsuya, H. Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Sci Rep, 10:10664-10664, 2020 Cited by PubMed: 32606378DOI: 10.1038/s41598-020-65993-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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