6OXO

HIV-1 Protease NL4-3 WT in Complex with LR2-91

Summary for 6OXO

Entry DOI	10.2210/pdb6oxo/pdb
Descriptor	Protease NL4-3, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[{[4-(hydroxymethyl)phenyl]sulfonyl}(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate, ... (4 entities in total)
Functional Keywords	hiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22706.66
Authors	Lockbaum, G.J.,Rusere, L.N.,Lee, S.K.,Henes, M.,Kosovrasti, K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,KurtYilmaz, N.,Schiffer, C.A.,Ali, A. (deposition date: 2019-05-14, release date: 2019-08-21, Last modification date: 2024-03-13)
Primary citation	Rusere, L.N.,Lockbaum, G.J.,Lee, S.K.,Henes, M.,Kosovrasti, K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,Yilmaz, N.K.,Schiffer, C.A.,Ali, A. HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope. J.Med.Chem., 62:8062-8079, 2019 Cited by PubMed: 31386368 DOI: 10.1021/acs.jmedchem.9b00838 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.003 Å)

Structure validation