6OWC

Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.

Summary for 6OWC

• Entry DOI: 10.2210/pdb6owc/pdb
• Descriptor: Estrogen receptor, (2Z)-N,N-dimethyl-4-{[2-({5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-2H-indazol-5-yl)-2-phenylbut-1-en-1-yl]pyridin-2-yl}oxy)ethyl]amino}but-2-enamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: nuclear hormone receptor, h3b-6545, inhibitor, serm, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 59878.26

Authors

Larsen, N.A. (deposition date: 2019-05-09, release date: 2019-06-19, Last modification date: 2024-10-30)

• Primary citation: Furman, C.; Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)