6OW7

X-ray Structure of Polypeptide Deformylase with a Piperazic Acid

Summary for 6OW7

DescriptorPeptide deformylase, NICKEL (II) ION, SULFATE ION, ... (5 entities in total)
Functional Keywordsinhibitor, complex, metal protein, enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceStreptococcus pneumoniae
Total number of polymer chains2
Total molecular weight46296.17
Authors
Campobasso, N.,Spletstoser, J.,Ward, P. (deposition date: 2019-05-09, release date: 2019-06-26)
Primary citation
Spletstoser, J.T.,Dreabit, J.,Knox, A.N.,Benowitz, A.,Campobasso, N.,Ward, P.,Cui, G.,Lewandowski, T.,McCloskey, L.,Aubart, K.M.
Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
Bioorg.Med.Chem.Lett., 2019
PubMed: 31160176 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2019.05.028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.45 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21830 0.3% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution