6OVC
hMcl1 inhibitor complex
Summary for 6OVC
Entry DOI | 10.2210/pdb6ovc/pdb |
Related | 2MHS |
NMR Information | BMRB: 30610 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, (2S)-N-(benzylsulfonyl)-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide (2 entities in total) |
Functional Keywords | inhibitor, mcl1 small molecule complex, apoptosis, apoptosis-inhibitor complex, apoptosis/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19411.83 |
Authors | Poppe, L. (deposition date: 2019-05-07, release date: 2019-05-22, Last modification date: 2024-05-01) |
Primary citation | Caenepeel, S.,Brown, S.P.,Belmontes, B.,Moody, G.,Keegan, K.S.,Chui, D.,Whittington, D.A.,Huang, X.,Poppe, L.,Cheng, A.C.,Cardozo, M.,Houze, J.,Li, Y.,Lucas, B.,Paras, N.A.,Wang, X.,Taygerly, J.P.,Vimolratana, M.,Zancanella, M.,Zhu, L.,Cajulis, E.,Osgood, T.,Sun, J.,Damon, L.,Egan, R.K.,Greninger, P.,McClanaghan, J.D.,Gong, J.,Moujalled, D.,Pomilio, G.,Beltran, P.,Benes, C.H.,Roberts, A.W.,Huang, D.C.,Wei, A.,Canon, J.,Coxon, A.,Hughes, P.E. AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. Cancer Discov, 8:1582-1597, 2018 Cited by PubMed: 30254093DOI: 10.1158/2159-8290.CD-18-0387 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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